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Naturally Occurring Cell-Mediated Immunity to Purified Glycerol-Teichoic Acid Antigen in Guinea Pigs

From The Ohio State University, Columbus, Ohio 43210

Abstract

Previous reports of delayed hypersensitivity in guinea pigs have dealt only with animals artificially immunized with the antigen used to elicit the delayed reaction (1–5). Except for delayed-type isohypersensitivity to serum protein antigens (6), no reports have described a naturally occurring cell-mediated immunity in this species. Although it has been established that delayed hypersensitivity to polysaccharides occurs in a number of mammalian species (7–12), only two investigators have reported using completely defined carbohydrates as the eliciting antigen (10, 11). No previous reports of delayed-type hypersensitivity to teichoic acids in any species have been published, although an immediate reaction to one of these antigens has been demonstrated in humans (13). This report describes the occurrence of delayed hypersensitivity to glycerol-teichoic acid in unimmunized guinea pigs as demonstrated in vivo by a delayed skin reaction and in vitro by the inhibition of macrophage migration.

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				A. Wicken and K. Knox Lipoteichoic acids: a new class of bacterial antigen Science, March 28, 1975; 187(4182): 1161 - 1167. [PDF]