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Dissociation of MIF Production and Cell Proliferation

From the Departments of Microbiology and Immunology and Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

The principal methods currently employed to explore the mechanism of cell-mediated immunity are blast cell transformation, production of soluble mediators and direct lymphocyte-target cell cytotoxicity. It is important to understand the nature of the cell detected in each of these assays in vitro, and to establish its relationship to the cell-mediated response in vivo.

While it appears clear that the induction phase in sensitization requires the proliferation of stem cells to fully competent lymphocytes, there is considerable evidence in vivo to suggest that the effector arm of the response does not require cell proliferation. The most obvious example in vivo of this is the well known radiation resistance of the cell-mediated immune response in comparison to the humoral responses (1, 2). Additionally, cells treated with mitomycin C, under conditions in which they can synthesize some RNA and protein but cannot divide, are capable of effecting passive transfer (3).

Footnotes

¹ Supported by United States Public Health Service Grant AI-07118 and Career Development Award 5K03-19996.

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