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In Vivo Studies of the Role of Cytotoxic T Cells in Tumor Allograft Immunity

From the Department of Immunology, Swiss Institute for Experimental Cancer Research, 1011 Lausanne, Switzerland

Abstract

Intraperitoneal growth of (DBA/2) P-815 tumor cells in heavily irradiated C3H mice was prevented by intravenous or intraperitoneal injection of immune, but not normal, C3H spleen cells. Tumor rejection occurred also in irradiated animals reconstituted with a pure population of immune thymus-derived (T) cells, free of bone marrow-derived (B) lymphocytes and alloantibody-forming cells. Immune spleen cells depleted of T cells were ineffective, although they contained the full complement of IgM alloantibody-forming cells. Intravenous injection of immune T cells also prevented the subcutaneous growth of P-815 cells in heavily irradiated C57BL/6 recipients. It is concluded that immune T cells played a predominant role in the rejection of allogeneic tumor cells.

Footnotes

¹ Supported by United States Public Health Service Career Development Award 6K3-HD-22,587, National Institute of Child Health and Human Development and by Research Grant 4767, Institute of Allergy and Infectious Disease. Present address: Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510.

² Supported by research grants from the Swiss National Foundation for Scientific Research.

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