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Enhancement of Mouse Thymus Cells Response to Periodate Treatment by a Soluble Factor¹

From the Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel and the Department of Medical Ecology, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Abstract

Mouse lymph node and spleen lymphocytes are stimulated by sodium periodate (NaIO₄) treatment, whereas mouse thymus cells show a minimal response. Hydrocortisone-resistant thymus cells are much more responsive to phytohemagglutinin than NaIO₄ treatment. Thymus cells are rendered highly responsive to NaIO₄ treatment upon addition of cell-free supernatants of mouse spleen cell and macrophage cultures. Treatment of mouse spleen cells and macrophages with NaIO₄ stimulates the production of the enhancing factor for thymus cell response.

Footnotes

¹ This work was supported by Grant No. 635125 from the National Institutes of Health of the United States Public Health Service.