HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Doria, G. Articles by Mancini, C. Search for Related Content PubMed Articles by Doria, G. Articles by Mancini, C.

The Rise and Fall of Antibody Avidity at the Level of Single Immunocytes¹

From the CNEN-Euratom Immunogenetics Group, Laboratory of Animal Radiobiology, C.S.N. Casaccia (Rome), Italy

Abstract

Antibody avidity for trinitrophenyl (TNP) was investigated at the level of single immunocytes in spleen cell populations from mice immunized by intravenous injection of TNP horse red blood cells. Early variations of avidity were observed before any significant increase in anti-TNP plaque forming cells (PFC) number was noticed. Subsequently, avidity increased with time, reached a maximum when the number of PFC attained the peak value, and then decreased as PFC were disappearing from the spleen. A 10⁴-fold variation in antigen dose did not affect this pattern. Avidity and PFC number decreased with lower antigen doses.

Footnotes

¹ Supported by CNEN-Euratom Association Contract. Publication 798 of the Euratom Biology Division.