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Studies on the Properdin System: Isolation of a Heat-Labile Factor from Guinea Pig Serum Related to a Human Glycine-Rich Beta-Glycoprotein (Gbg or Factor B)¹

From the Department of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Abstract

A heat-labile factor (HLF), which is essential for C3 inactivation by purified cobra venom factor, has been isolated from guinea pig serum. In addition to HLF, other protein(s) are required for inactivation of C3 by the cobra venom factor. HLF has a molecular weight of about 100,000 and is antigenically related to the human glycine-rich beta-glycoprotein (GBG). HLF is believed to be the guinea pig counterpart of factor B of the human properdin system.

Footnotes

¹ This work was supported in part by National Science Foundation Grants GB 7406X1 and GB 8323 A#1, National Institutes of Health Research Grant 5-RO1-AI-02566-13, and NIH Training Grant TO1-AI00-282-08.

² Supported by a grant from the DAAD (4-nato-3/k).

³ Recipient of NIH Career Development Award 6-KO4-GM50193-01.