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Porcine Immunoglobulins

II. Antibody Response of Adult Swine to Bovine Globulin

From the Arthritis and Rheumatism Branch of the National Institute of Arthritis and Metabolic Diseases and the Laboratory of Clinical Investigation of the National Institute of Allergy and Infectious Diseases

Abstract

Antibody activity was demonstrated in each of six porcine immunoglobulins by the technique of indirect radioimmunodiffusion. Anti-BGG antibody of IgM, IgA and IgG classes were detected in serum simultaneously on the 4th day after primary immunization. The acquisition of antibody activity in the IgG subclasses was variable and no clear pattern was seen. IgA antibody reached peak titer last among the major classes and was the first to decline.

Footnotes

¹ Present address: Department of Medicine, University of California, San Francisco, California 94122.

² Present address: Division of Rheumatology, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, California 92037. (To whom inquiries should be addressed.)