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Porcine Immunoglobulins

I. Identification of Classes and Preparation of Specific Antisera

From the Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases and the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

Abstract

Methods described in this paper facilitated the rapid characterization of porcine immunoglobulins and the development of class-specific antisera. The methods are generally applicable to the immunoglobulins of any species. In this paper, data are presented which demonstrate that the sera of adult swine contain IgG, IgM and IgA. IgG appears to consist of at least three, and possibly four, subclasses.

Footnotes

¹ Present address: Department of Medicine, University of California, San Francisco, California 94122.

² Present address: Rheumatology Division, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, California 92037 (to whom inquiries should be addressed).