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Genetic Regulation of the Thymus Dependent Humoral Immune Response in Leukemia Prone Akr (H-2^k) and Nonleukemic C3H (H-2^k) Mice

Description of Genetic Control of the Immune Response at the Level of Proliferation

From the University of Tennessee, Oak Ridge Graduate School of Biomedical Sciences, and the Biology Division, Oak Ridge National Laboratory, ^,3 Oak Ridge, Tennessee 37830

Abstract

Defective immunopoiesis in young adult AKR mice has been shown to be genetically regulated. Transfer of identical numbers of cells from the same spleen cell suspension into x-irradiated young adult mice of the AKR and C3H strains, the F₁ and F₂ progeny of these two strains, and the progeny of the two F₁ backcrosses has provided direct evidence that the regulation of immunocompetent cell proliferation is genetic in nature. Statistical tests indicate that the evidence for genetic differences is consistent with a single, apparently non-H-2, autosomal gene locus.

Footnotes

¹ University of Tennessee Postdoctoral Trainee. National Institute of Child Health and Human Development (Grant HD-0296).

² Present address: Gerontology Research Center, Baltimore City Hospital, Baltimore, Maryland 21224.

³ Operated by Union Carbide Corporation for the United States Atomic Energy Commission.