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The Journal of Immunology, 1972, 109: 957-960.
Copyright © 1972 by The American Association of Immunologists, Inc.
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Production of Antibody to Homologous {alpha}-Fetoprotein in Rabbits, Rats and Horses by Immunization with Human {alpha}-Fetoprotein

Shinzo Nishi, Hiroyuki Watabe and Hidematsu Hirai

From the Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan

Abstract

Rabbits, rats, horses and a dog were immunized with purified human {alpha}-fetoprotein. High titered antibodies were produced except in the case of the dog. The rabbit, rat and horse antibodies cross-reacted with their own homologous {alpha}-fetoprotein. Attempts to produce antibody with homologous {alpha}-fetoprotein in rabbits, rats and dogs were not successful.






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