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The Immune Response in Mice to the Haptenic Determinant Dnp Coupled to a Thymus-Independent Carrier (Levan)

From the Department of Experimental Immunobiology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England and Chester Beatty Research Institute, Royal Cancer Hospital, Fulham Road, London SW3, England

Abstract

A thymus-independent antigen (levan) can function as a carrier and induce the synthesis of antibodies to DNP. The DNP-levan conjugate is able to elicit only 19S antibody against the hapten. This immune response is not affected in thymectomized mice, but is abolished in mice tolerant to levan. A mechanism involving cooperation between hapten-specific B lymphocytes and carrier-specific B lymphocytes is suggested to account for these findings.

Footnotes

¹ Seconded from INSERM (France) in receipt of a Fellowship from the M.R.C. (U.K.).

² Correspondence: Institut d'Immunobiologie, Hôpital Broussais, Paris 14, France.