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H-2 Dependence of Co-Operation Between T and B Cells in Vivo

From the Immunology Unit, Department of Biology, University of Konstanz, Konstanz, Germany and the Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48104

Abstract

In nude mice from a stock which has been backcrossed several times to BALB/c (H-2^d), a lasting restoration of immune competence could be induced by H-2 compatible (BALB/c, DBA, B10.D2) thymus cells but not by H-2 incompatible thymus cells. Heterozygous, H-2^bH-2^d, thymus cells from BALB/c x C57, F₁ or from a BALB/c x (BALB/c x C57) backcross produce variable effects; only sometimes was a lasting restoration achieved. This cannot be accounted for by rejection of the injected thymus cells since nude mice do not reject tissue grafts. Therefore the H-2 complex must play an active role in an enduring co-operation between bone marrow-derived (B) cells and thymus-derived (T) cells.

Footnotes

¹ Immunology Unit, Department of Biology, University of Konstanz, Konstanz, Germany. Present address: Basel Institute for Immunology, Grenzacherstr. 487, CH-4058 Basel, Switzerland.

² Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48104. Address for 1971–72: Basel Institute for Immunology, Grenzachstr. CH-4058 Basel, Switzerland.

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