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Alpha and Gamma Heavy Chain Diseases in Man: Intracellular Origin of the Aberrant Polypeptides

From the Laboratory of Immunochemistry of the Research Institute on Blood Diseases, Hopital Saint-Louis, Paris, France and the Rheumatic Diseases Study Group and Department of Medicine, New York University School of Medicine, Manhattan Veterans' Administration Hospital, New York, New York

Abstract

Immunofluorescent and in vitro labeling studies were carried out on cells obtained from patients with and heavy chain diseases. No evidence of post-ribosomal intracellular degradation of a normal size heavy chain was found in either case. Intracellular polymerization of the aberrant peptides appeared to take place in a fashion similar to that seen in cells synthesizing intact heavy chains.

Footnotes

¹ During the period of these studies, Dr. Buxbaum was a Visiting Scientist at the Hospital Saint-Louis supported by a grant from the French National Institute for Health and Medical Research (I.N.S.E.R.M.). The studies were also partially supported by CNRS Grant ERA 239. I.N.S.E.R.M. Contract 71-10-502.