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The Immunologic Specificity and Biologic Activity of Heterologous Anti-Human Sera¹

I. Properties of Rabbit anti-Human Fibroblast Sera

From the Transplantation and Immunology Division and the Institute of Reconstructive Plastic Surgery, Department of Surgery, New York University Medical Center, New York, New York 10016

Abstract

Cultured human fibroblasts obtained from normal donors were used to produce heteroantisera in rabbits. The resulting antisera contained high titers of cytotoxic antibodies against three major categories of cell surface antigens: 1) species-specific antigens present on all human tissues tested; 2) species-specific antigens shared by man and subhuman primates; 3) fibroblast-specific antigens. In addition, rabbit antisera against human fibroblasts contained non-cytotoxic precipitating antibodies against soluble antigen(s) present in fibroblasts, lymphocytes and in the ₁-glycoprotein fraction of normal human serum.

Footnotes

¹ This work was supported by a grant from The John A. Hartford Foundation, Inc.; supported in part by the Billy Rose Foundation, Inc.; The Irwin Strasburger Memorial Medical Foundation, Inc.; and Contract NONR-4503, Office of Naval Research, Washington, D. C.