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Disappearance and Recovery of Human Monocyte IgG Receptor Activity After Phagocytosis

From the Laboratory of Cellular and Subcellular Immunology, Department of Medicine, Mount Sinai School of Medicine, of The City University of New York, New York, New York 10029

Abstract

Human monocytes were incubated with latex or formalin pre-treated SRBC and tested for IgG receptor activity. After 10 min, receptor activity could not be detected in 90% of phagocytizing cells; after 6 hr, 78 to 84% of the monocytes recovered IgG receptors. The kinetic data and the morphologic observation of selective sites of membrane binding suggest internalization followed by recovery of monocyte plasma membrane IgG receptor sites.

Footnotes

¹ This investigation was supported by United States Public Health Service Research Grant AI-09338. Dr. S. D. Douglas is the recipient of a Career Development Award 5 KO4 HL 42575-03 from the National Heart and Lung Institute. Dr. M. E. Schmidt is a visiting Research Fellow supported by a grant from the Max-Kade Foundation, New York, New York.

² Present address: Laboratory of Cellular and Subcellular Immunology, Atran 118, Mount Sinai School of Medicine, 100th Street and 5th Avenue, New York, N. Y. 10029.