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Production of Antibody in the Canine Tracheal Pouch after Local and Systemic Influenza Immunization¹

From the Allergy-Immunology and Infectious Disease-Hypersensitivity Sections, Department of Medicine, Northwestern University Medical School and The Clinical Virology Laboratory, Department of Pathology, Passavant Memorial Hospital, Northwestern University-McGaw Medical Center, Chicago, Illinois 60611

Abstract

The canine tracheal pouch model was utilized to compare the secretory and systemic immune response to topical tracheal or subcutaneous immunization with influenza A, swine strain, and influenza B viruses. Serum antibody responses were comparable regardless of the route of administration of virus, but topical tracheal immunization was more effective than subcutaneous immunization for eliciting anti-influenza antibody in tracheal secretions. Both IgG and IgA anti-influenza antibodies were found in tracheal secretions after topical immunization. The IgA response was consistent with the presence of local antibody production. In addition, tracheal secretions contained a nonspecific inhibitor of influenza hemagglutinating activity which reacted to high titer with A² influenza virus and was susceptible to receptor-destroying enzyme.

Footnotes

¹ Supported, in part, by United States Public Health Service Training Grant A I 00057, the Ernest S. Bazley Grant, and General Research Support Grant No. FR 05370.