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Complement-Unlike Hemolytic Activity in Lobster Hemolymph¹

From the Department of Pathology, Duke University and The University of Pennsylvania, Philadelphia, Pennsylvania, 19104

Abstract

Hemagglutinating and cobra venom factor (CVF)-activated hemolytic activities were found in the hemolymph of the lobster, Homarus americanus. The substances in hemolymph responsible for these two activities were separated and shown to be mutually independent. Hemolytic activity was due to the action of a low level of phospholipase A in the CVF preparation on lobster hemolymph lipoprotein. Lecithin was converted to lysolecithin. Phospholipase A activity was also demonstrated in a commercial preparation of CVF. Lecithin and human lipoproteins as well as lobster lipoproteins were suitable substrates for both CVF preparations.

Footnotes

¹ This work was supported by National Institutes, of Health GMS Grants 5-TI-GM726, AM 14372, HE 13931 and AM 13515.