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Serologic Identity of the b4 Allotypic Determinants Present on Homogeneous Rabbit Light Chains with Different N-Terminal Amino Acid Sequences¹

From the Rockefeller University, New York, New York 10021

Abstract

Homogeneous rabbit light chains with marked differences in their N-terminal sequences possess identical b4 allotypic markers. Homogeneous antibodies isolated from b4 rabbits absorbed anti-b4 antisera with the same efficiency as a pool containing multiple b4 light chains. These results indicate that the molecular determinant(s) of the b4 allotype is not related to the sequence variations at the N-terminus of the light chains. The same b4 allotypic marker is present on homogeneous light chains even though they have marked differences in electrophoretic mobility and amino acid composition. These data suggest that the b4 determinant is in the constant region or in a constant part of the variable region of the rabbit light chain.

Footnotes

¹ This work was supported by the National Institutes of Health Research Grants AI-08429, AI-00394, and a National Institutes of Health Biomedical Sciences Support Grant RR-07065.

² Established Investigator, American Heart Association.

³ National Science Foundation Graduate Fellow.