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Lymphocyte Classes in New Zealand Mice

II. Decreased Frequency of Immunoglobulin-Bearing Lymphocytes and Increased Frequency of Lymphocytes Lacking Detectable or Immunoglobulin Determinants

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and Division of Clinical Immunology and Arthritis, Veterans' Administration Hospital and the University of California, San Francisco, California 94121

Abstract

Newborn through 1-year-old NZB mice demonstrate a 30 to 50% decrease in the frequency of -bearing splenic lymphocytes, compared to similarly aged BALB/c mice. In addition, the frequency of immunoglobulin-bearing cells among lymph node and spleen cell populations of 6-week-old NZB, NZW and (NZB x NZW)F₁ mice is substantially decreased compared to five normal strains. In NZ animals, the immunoglobulin-bearing cells appear to be replaced by a nonthymus-derived lymphocyte which lacks detectable or chain determinants. Although the significance of these cells is yet uncertain, they may be an early manifestation of a basic immunologic defect in NZ animals.

Footnotes

¹ Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014.

² Division of Clinical Immunology and Arthritis, Veterans' Administration Hospital and the University of California, San Francisco, California 94121.