HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Halpern, M. S. Articles by Coffman, R. L. Search for Related Content PubMed Articles by Halpern, M. S. Articles by Coffman, R. L.

Polymer Formation and J Chain Synthesis in Mouse Plasmacytomas¹

From the Department of Microbiology, University of Southern California School of Medicine, Los Angeles, California 90033 and the Salk Institute for Biological Studies, La Jolla, California 92037

Abstract

Three out of four cloned mouse plasmacytoma cell lines examined synthesized and secreted polymeric IgA with covalently bound J chain, thus establishing that J is synthesized by the plasma cell. A fourth cell line synthesized and secreted only monomer (7S) IgA which contained no J chain. In the immunoglobulin secreted by the polymer-secreting lines, J was not bound to monomer and was added to polymer at or very near the time of polymerization. These results are consistent with the suggestion that polymer assembly is mediated by J chain.

Footnotes

¹ This investigation was supported by National Institutes of Health Grant A 105875 and Training Grant AI 00430 and American Cancer Society, California Division, Grant 587.

² Recipient of United States Public Health Service Training Fellowship GM 00702-11.