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Intravaginal Immunization of Humans with Candida Albicans¹

From the University of Florida College of Medicine Gainesville, Florida 32601 and the World Health Organization Immunology Laboratory Lausanne, Switzerland

Abstract

Ten women were immunized intravaginally with a Candida albicans vaccine. Antibody was measured by a radioactive single radial immunodiffusion technique, and antibody activity was expressed as the area of the precipitin ring. The mean rise in serum antibody was 41 to 66 mm². The mean rise in cervicovaginal secretion antibody was from <12 mm² to 74 mm². The cervicovaginal secretion antibody was removed by absorption with anti-IgA, but not appreciably by anti-IgG or anti-IgM. These results suggest that cervicovaginal secretion IgA antibody is locally produced and can be stimulated by local application of antigen.

Footnotes

¹ This work was supported in part by the Unit of Human Reproduction of the World Health Organization.