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Structural Differences in Mouse IgA Myeloma Proteins of Different Allotypes¹

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, 3050. Australia

Abstract

Mouse IgA myeloma proteins produced by plasma cell tumors derived from BÀLB/c, NZB and (BALB/c x NZB)F₁ hybrid mice were examined electrophoretically under dissociating conditions by using reduced and unreduced samples. In confirmation of previous studies by Abel and Grey (3) our electrophoretic patterns are consistent with the conclusion that no L-H disulfide bonds are present in BALB/c-derived IgA proteins. However, 3 out of 3 NZB derived IgA proteins appeared to possess L-H disulfide bonds, as did 5 of 10 NZB hybrid derived proteins. The presence of L-H disulfide bonds in the hybrid-derived proteins completely correlated with the presence of Ig-2^e (NZB type) IgA allotypic antigens.

Footnotes

¹ This is publication number 1699 of the Walter and Eliza Hall Institute. This work was supported by Research Grant AM-11234-04 from the United States Public Health Service.