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Lymphocyte Subpopulations in NZB Mice: Deficit of Thymus-Dependent Lymphocytes¹

From the Departments of Pathology and Laboratory Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, 55455

Abstract

The relative and absolute numbers of thymus-dependent lymphocytes (positive for isoantigen) and of thymus-independent lymphocytes (positive for membrane immunoglobulins or for antigen-antibody-complement receptors) were studied in the lymphoid tissues of NZB and CBA/H mice. The ages of the mice ranged from 100 to 600 days. A progressive decline of -positive lymphocytes was observed with age in NZB, but no such decay was detected in CBA/H mice, a non-autoimmune strain. The decline of -positive lymphocytes was observed in NZB mice as early as 200 days of age and appeared even in absence of detectable signs of autoimmunity, although the decline was accentuated by the development of autoimmunity and by progressive age. No such changes were observed for the thymus-independent lymphocytes, and only a moderate increase of these cells was observed with age both in NZB and CBA/H strains.

Footnotes

¹ This work was supported by United States Public Health Service Grants CA-12865 and AI-10153 and from the National Foundation March of Dimes. Part of this work was Presented at the First International Congress of Immunology, Washington, D. C., August, 1971.

² Research Associate of the American Cancer Society.