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Antigen-Induced Inhibition of Experimental Allergic Encephalomyelitis

I. Inhibition in Guinea Pigs Injected with Non-Encephalitogenic Modified Myelin Basic Protein^{1 ,2}

From the Department of Microbiology, Wayne State University, School of Medicine, Detroit, Michigan 48201

Abstract

Encephalitogenic basic protein (BP) was isolated from bovine brain. Portions of BP preparations were rendered non-encephalitogenic for guinea pigs by modification of the single tryptophan residue with 2-hydroxy-5-nitrobenzyl bromide. This modified BP (benzyl-BP) was employed for antigen-induced inhibition of experimental allergic encephalomyelitis (EAE). In some experiments, non-encephalitogenic diazonium derivatives of BP were also employed for inhibition. The results show that non-encephalitogenic modified BP preparations are capable of suppressing EAE when administered to previously sensitized guinea pigs. On the other hand, if the animals were treated before sensitization, EAE was almost completely prevented. Moreover, the modified preparations inhibited the disease as effectively as unmodified BP.

Footnotes

¹ This work was supported by Research Grant 649-A-1 from the National Multiple Sclerosis Society.

² Presented in part at the annual meeting of the American Association of Immunologists, Chicago, April, 1971. (Fed. Proc., 30: 305 Abstract, 1971.)

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