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Histocompatibility-Linked Genetic Control of the Immune Response to Hapten Guinea Pig Albumin Conjugates in Inbred Guinea Pigs

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland and the Department of Pathology, Harvard Medical School, Boston, Massachusetts

Abstract

The immune response of inbred guinea pigs to low doses of hapten-guinea pig albumin conjugates is controlled by a specific immune response gene closely linked to the gene complex controlling strain 13 histocompatibility antigens. Thus, strain 13 guinea pigs make significant anti-dinitrophenyl (anti-DNP) antibody responses to 1 µg of DNP-guinea pig albumin (GPA) while strain 2 guinea pigs make little or no response and are not prepared for secondary anti-DNP responses. Progeny of (2 x 13) F₁ x 2 matings which possess strain 13 histocompatibility antigens are good responders to a low dose of DNP-GPA while offspring lacking strain 13 antigens are poor responders. The differential response of strain 2 and 13 animals to DNP-GPA is also observed with p-iodophenylsulfonyl-GPA and a 3-(2,4-dinitrophenylamino)-propylamide derivative of GPA. These observations indicate that this immune response gene is involved in carrier recognition and suggest that it operates in thymus-derived lymphocytes.