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Chicken Immunoglobulin Resembling A¹

From the Departments of Medicine and Pathology, McMaster University, Hamilton, Ontario, and Department of Medicine and Institute of Immunology, University of Toronto, Toronto, Ontario, Canada

Abstract

The immunoglobulin classes recognized in the chicken are G and M. Because of an interest in this laboratory in the mechanisms of local mucosal immunity and the possible experimental manipulations of chicken central lymphoid tissue, it was felt that a redefinition of chicken immunoglobulins, particularly with reference to a possible A class, should be undertaken before a satisfactory exploration of mucosal immunity in the chicken could occur. Accordingly, we immunized a rabbit against chicken G Fab fragments prepared according to the methods of Tenenhouse and Deutsch (1). We further prepared antisera in goats to chicken M and G heavy chains as described previously (2). The anti-chicken G was monospecific for the chain, and did not react with Fab fragments. The anti-M antiserum was rendered monospecific by absorption with newly hatched chicken serum. Both antisera gave single precipitin arcs in immunodiffusion experiments against normal chicken serum.

Footnotes

¹ Supported by the Medical Research Council of Canada.

² MRC Scholar.

³ Q. Elizabeth II Scientist.