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The Response to SRBC by Nude Mice Injected with Lymphoid Cells Other Than Thymus Cells

From the Immunology Unit, Department of Biology, University of Konstanz, Konstanz, Germany

Abstract

Nude mice from a stock partially backcrossed to BALB/c were able to produce hemagglutinating antibody if they were injected with BALB/c-Ig^b spleen, lymph node, peritoneal or educated T cells. C57 spleen cells and, in one experiment, BALB/c-Ig^b bone marrow cells induced only a transitory responsiveness. Usually bone marrow cells had no apparent effect on the ability to produce hemagglutinating antibody, nor did BALB/c-Ig^b fetal cells from thymus, spleen or liver.

The allotype of the serum antibody was studied by facilitated hemolysis. In nude mice, regardless of the type of cell injected, the antibody was almost always of host type although donor type antibody predominated if the cells were injected into irradiated BALB/c.

Footnotes

¹ Present address: Basel Institute for Immunology, Basel, Switzerland.