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Defective in Vitro Spleen Cell Proliferative Response to Antigens in Agammaglobulinemic Chickens

From the National Institutes of Health, National Institute of Dental Research and National Cancer Institute, Bethesda, Maryland 20014

Abstract

Cyclophosphamide treatment of chickens during early extraembryonic life selectively inactivates B cells as indicated by the induction of agammaglobulinemia and the lack of proliferative response of their spleen cells to anti-immunoglobulin. T cell functions as measured by the response to phytomitogens, anti-thymocyte serum and irradiated allogeneic cells in the mixed leukocyte reaction were found to be intact. However, the in vitro proliferative response to specific antigens was significantly diminished in agammaglobulinemic chickens which suggests that B cell participation may be required for this response.

Footnotes

¹ Supported by a training grant from the Deutsche Forschungsgemeinschaft.