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Chemical Carcinogenesis and Humoral Antibody Synthesis¹

From the Department of Medical Immunology, The Public Health Research Institute of the City of New York Inc., New York, New York 10016

Abstract

Methylcholanthrene in an amount sufficient to induce tumors in 100% of injected mice failed to influence humoral antibody responses as estimated by activity or weight measurements. Mice injected with the carcinogen before or after immunization with sheep erythrocytes and human serum albumin responded at the same levels during the primary and secondary phases of antibody synthesis as did the controls. The early immune response in tumor-bearing mice was also indistinguishable from that of normal animals, despite the presence of marked splenomegaly in the former group.

Footnotes

¹ Support for this investigation was received, in part, from the National Science Foundation, Grant GB-7404X; the American Cancer Society, Inc., Grant T-257 and the National Institute of Allergy and Infectious Diseases of the United States Public Health Service, Grant AI-08710.

² On leave from Institute of General Pathology, Palermo, Italy.

³ Present address: Instituto de Investigaciones Médicas, Buenos Aires, Argentina.