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Bidirectional Effects of Interaction between Parental Thymocytes and F₁ Spleen Cells in the Production of Graft vs Host Splenomegaly¹

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510

Abstract

The addition of 1.5 x 10⁷ F₁ spleen cells to inocula of parental thymocytes in sublethally irradiated F₁ hosts influenced the resultant splenomegaly. The influence of the F₁ cells was bidirectional; under certain conditions they increased the splenomegaly while under others they decreased it. Analysis of these conditions revealed that the effect the F₁ cells had depended on the activity of the parental thymocytes. Active thymocytes produced small spleens when inoculated alone; the smaller the spleen the greater the synergy with F₁ cells. On the other hand less active thymocytes occasionally produced some splenomegaly on their own. When they did, added F₁ cells reduced the spleen size (acted "antergistically"). The mechanism(s) by which these bidirectional effects of F₁ cells may be expressed are discussed.

Footnotes

¹ This work was supported by Grant CA-08593 from the National Cancer Institute, a Grant of the Anna Fuller Fund.

² Richard K. Gershon is a recipient of Career Development Award CA-10,316 from the National Cancer Institute.