HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) An erratum has been published Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Youmans, G. P. Articles by Youmans, A. S. Search for Related Content PubMed Articles by Youmans, G. P. Articles by Youmans, A. S.

The Effect of Mycobacterial RNA on the Primary Antibody Response of Mice to Bovine Globulin

From the Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

Abstract

Mycobacterial RNA-protein preparations, obtained from viable cells of the attenuated H37Ra strain, will stimulate the production of antibody to bovine globulin in mice in a manner and intensity comparable to that of the synthetic polynucleotides poly A:U or poly I:C. In this respect, though, the mycobacterial RNA was less effective than Escherichia coli endotoxin or the double-stranded coliphage Mu-9 ds-RNA. The adjuvant activity of mycobacterial RNA was reduced by treatment with ribonuclease or with trypsin. The possible role of mycobacterial RNA in the adjuvant activity of intact mycobacterial cells is discussed.