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The Journal of Immunology, 1972, 109: 213-216.
Copyright © 1972 by The American Association of Immunologists, Inc.
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Antineuraminidase Antibody Response of Man to Influenza Virus Neuraminidase N2: Results Obtained with an Improved Hemagglutination Inhibition Technique and an Enzyme Inhibition Test1

Albert V. Hennessy, Elva Minuse and Fred M. Davenport

From the Department of Epidemiology, School of Public Health, The University of Michigan, 109 Observatory Street, Ann Arbor, Michigan 48104

Abstract

Sets of sera obtained from subjects vaccinated or infected with influenza A2 strains from 1957 to 1968 were examined by an improved hemagglutination inhibition procedure for measuring antineuraminidase antibodies with recombinant viruses, and by a neuraminidase inhibition test with human serum Cohn fraction IV-4 as substrate. Recombinants prepared with viruses containing 1957 and 1968 antigenic variants of neuraminidase were employed. The improved HI procedure was found to be as reliable as the NI test for detecting antineuraminidase antibody and antineuraminidase antibody increase. Antineuraminidase antibody was generally not found on first exposure to A2 strains but antibody increase occurred with increasing frequency during subsequent years. The antineuraminidase antibody response of man is broad, making recognition of antigenic enzymatic variants difficult by use of human serum.

Footnotes

1 This work was done under the sponsorship of the Commission on Influenza, Armed Forces Epidemiological Board, and was supported by the United States Army Medical Research and Development Command, Department of the Army, under Research Contract DADA 17-70-C-0050.






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