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Effect of Haptens on the Reaction of Anti-Idiotype Antibody with a Mouse Anti-Phosphorylcholine Plasmacytoma Protein¹

From the Salk Institute for Biological Studies, San Diego, California 92112

Abstract

In a radioimmune assay under conditions of excess antigen, the binding of a mouse antiphosphorylcholine plasmacytoma protein by anti-idiotype antibody is partially inhibited by phosphorylcholine and related haptens. The effect of these haptens on the idiotype correlates with the affinity with which they are bound by the plasmacytoma protein.

Footnotes

¹ This work was supported by National Institutes of Health Grant (A-105875) and a Training Grant (AI-00430) to Dr. Melvin Cohn.

² Now with National Institute for Medical Research, Mill Hill, London, N. W. 7, England. Recipient of United States Public Health Service Training Fellowship GM-00702.