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The Distribution of Brain-Associated Antigen Cross-Reactive with Mouse in the Brain of Other Species¹

From the Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907

Abstract

is a mouse alloantigen which serves as a marker for thymus-derived (T) cells (1). Anti- antisera have proven to be powerful tools in elucidating the roles of bone marrow-derived (B) and T lymphocytes (2). is shared by T lymphocytes and brain tissue in the mouse (1). We had previously shown (3) that immunization of rabbits and goats with mouse brain results in the production of potent anti--like antisera. We have termed these anti-brain-associated antisera (BA). It would be a great advantage in studying immune systems other than the mouse if antigen comparable to were available. We have taken a variety of approaches in an attempt to develop anti--like antisera to other species. One of these is to investigate brain tissue of other species to determine if it contains cross-reacting antigens with mouse BA.

Footnotes

¹ This work was supported by United States Public Health Service Grant AI-08800 and a Faculty Development Award from the Merck Foundation.

² Recipient of a United States Public Health Service Research Career Development Award.

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