HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dupouey, P. Search for Related Content PubMed Articles by Dupouey, P.

Role of the Cerebrosides and a Galactodiglyceride in the Antigenic Cross-Reaction Between Nerve Tissue and Treponema

From the Laboratoire de Biochimie des Antigènes Institut Pasteur, Paris

Abstract

Various authors have demonstrated an antigenic identity between nervous tissue and treponema. This report shows that this antigenic identity is due to the presence in the treponema extracts of a galactodiglyceride hapten: i.e, 2,3-di-O-acyl-1-O-(-D-galactopyranosyl)-D-glycerol. This hapten shows a cross-reaction with the cerebrosides; moreover, the nervous tissue contains a lipid which, on deacylation, liberates a O-(-D-galactosyl)-1-1'-glycerol (11). The part played by each of the constituents as well as the possible consequences of this antigenic community are discussed.