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Migration Inhibition of Peripheral Leucocytes in Human Schistosomiasis

From the Parasitology Section, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, United States Department of Health, Education and Welfare, Atlanta, Georgia 30333

Abstract

Migration inhibition of peripheral leucocytes by extracts of Schistosoma mansoni was observed in individuals who showed delayed-type skin reactivity with the parasitic antigen. There was no correlation between the in vitro migration inhibition and immediate-type hypersensitivity, the presence of specific antibody to S. mansoni in the serum, nor a nonspecific serum factor. A correlation between migration inhibition of peripheral leucocytes and delayed skin reactivity was observed in individuals hypersensitive to Brucella abortus.

Footnotes

¹ Present address: Department of Experimental Pathology, Allergy and Immunology, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, California 92037.

² Address correspondence to: Dr. I. G. Kagan, Center for Disease Control, Atlanta, Georgia 30333.