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The Pathogenesis of Aleutian Disease of Mink

II. Enhancement of Tissue Lesions Following the Administration of a Killed Virus Vaccine or Passive Antibody¹

From the Department of Pathology, University of California School of Medicine, Los Angeles, California 90024, the Department of Microbiology, University of Utah School of Medicine, Salt Lake City, Utah 84112 and the Fur Breeders' Agricultural Cooperative, Midvale, Utah

Abstract

Administration of an inactivated Aleutian disease virus vaccine to mink induced detectable antibody in one of 26 animals. When immunized mink were challenged with live virus, they developed more severe lesions than mink given a control vaccine. The immunized mink were also more susceptible to oral virus challenge than control mink. Passive administration of antiviral antibody at the peak of virus replication produced necrotizing acute inflammatory lesions, followed by mononuclear cell infiltrates.

Footnotes

¹ This study was supported by Grant AI-09476 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by grants from the Mink Farmers' Research Foundation, and the California Institute for Cancer Research.

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