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Immunogenicity of Soluble HL-A Alloantigens¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037, and the School of Medicine, University of California at Los Angeles, Los Angeles, California 90024

Abstract

In recent years extensive investigations have been directed toward determining the biologic and chemical profiles of soluble HL-A alloantigens isolated from a variety of tissue sources. During the course of such studies, the in vitro reactivity of these materials was established serologically by their ability to inhibit specifically cytotoxic alloantisera (1). The soluble HL-A antigens have been shown to have further immunologic significance as they can induce specifically blastic transformation of histoincompatible but not of isogeneic leukocytes in vitro (2). Chemical studies thus far suggest that HL-A antigens are essentially protein in nature and apparently consist of single polypeptide chains with a molecular weight of 31,000 (3). The data concerning the immunogenic properties of soluble HL-A alloantigens thus far are scanty and conflicting. Batchelor (4) reported that rabbits immunized with partially purified soluble HL-A substances produced only species-specific lymphocytotoxic antibodies.

Footnotes

¹ This is publication number 565 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This work was supported by Grants AI 10180 and CA 10596 from the National Institutes of Health, United States Public Health Service and Grant 70-615 from the American Heart Association, Inc.

² Visiting scientist from University of Milan, Italy.

³ Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

⁴ Visiting scientist from Istituto Regina Elena, Rome, Italy.

⁵ School of Medicine, University of California at Los Angeles, Los Angeles, California 90024.