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The Influence of Carriers on the Immune Response of Rabbits to the Synthetic Homopolymer Poly (-2-N-Morpholinylethyl-l-Glutamamide) (Pameg)¹

From the Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Abstract

Immunization intravenously (i.v.) of rabbits with soluble PAMEG, or PAMEG adsorbed to alum, carboxymethylcellulose, or insoluble acetylated bovine serum albumin produced little (0.05 mg antibody/ml serum) or no precipitating antibody against PAMEG. However, rabbits immunized with PAMEG coated onto a rough strain of Pneumococcus (R36A) produced significant levels of antibody directed against both PAMEG and the R strain carrier. After the second course immunization, the antiPAMEG response was as high as 16 mg antibody/ml serum, and some sera displayed restrictions in the globulin region by cellulose acetate electrophoresis.

Footnotes

¹ This work was supported by Grants TIAI-334 and AI-07825 from the National Institute of Allergy and Infectious Diseases and Public Health Service and also by Contract DADA 17-67-C-7021 from the Department of the Army, Office of the Surgeon General. Paper 47 in a series of Antigenicity of Polypeptides (Poly Amino Acids).