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Delayed Hypersensitivity in the Marsupial Setonix Brachyurus (Quokka)

From the Microbiology Department, The University of Western Australia, Perth, W. A.

Abstract

The capacity of the quokka (Setonix brachyurus) to develop a delayed hypersensitivity response to 2,4-dinitrofluorobenzene (FDNB) was demonstrated and the optimum conditions for it were determined. They were topical application of FDNB in ethyl alcohol (EtOH) for 10 days, challenge intradermally (i.d.) with FDNB in olive oil and reading after 48 hr. There was concomitant development of precipitating antibody to the chemical hapten.

Lymphocytes from normal quokkas undergo blast transformation in response to phytohemagglutinin (PHA).

In the one thymectomized quokka studied there was complete absence of both delayed hypersensitivity response to FDNB and leucocyte response to PHA. A humoral antibody response, however, was still present.

Footnotes

¹ All correspondence to K. J. T., Clinical Immunology Unit, Princess Margaret Hospital, Perth, Western Australia.