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Inhibition of Antichlamydial IgM Antibody by IgG Antibody in Immunofluorescence Tests¹

From the Department of Microbiology and Hooper Foundation, University of California, San Francisco, San Francisco, California 94122

Abstract

Monkeys inoculated intramuscularly with chlamydial suspensions responded with antibody demonstrable by indirect immunofluorescence. IgM antibody was not detected in the whole sera of five of six monkeys, but antibody activity could be demonstrated in IgM fractions from these sera. Monkeys inoculated intravenously with large numbers (10¹¹) of chlamydial particles had IgM antibody detectable in whole sera as well as in fractions. IgG antibody interfered with the demonstration of IgM antibody by immunofluorescence. It is suggested that similar interference of IgG with IgM antibody may occur in other systems.

Footnotes

¹ This study was supported by National Institutes of Health Grant EY 00186, United States Public Health Service Training Grant AI 00299, and by United States Army Medical Research and Development Command Contract DADA 17-69-C-9156.

In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences-National Research Council.

² Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy, University of California, San Francisco.

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