HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schneerson, R. Articles by Robbins, J. B. Search for Related Content PubMed Articles by Schneerson, R. Articles by Robbins, J. B.

An Escherichia Coli Antigen Cross-Reactive with the Capsular Polysaccharide of Haemophilus Influenzae Type b: Occurrence Among Known Serotypes, and Immunochemical and Biologic Properties of E. Coli Antisera Toward H. Influenzae Type b

From the Developmental Immunology Branch, National Institute of Child Health and Human Development, N. I. H. and the Charlotte Memorial Hospital, Charlotte, N. C.

Abstract

An Escherichia coli antigen was shown to be cross-reactive with the capsular polysaccharide of Hemophilus influenzae type b. The cross-reactive antigen was identified as a thermostable, acidic, capsular polysaccharide consistent with its designation as E. coli "K" antigen (type A). Antibodies raised by intravenous injection of formaldehyde-treated E. coli possessing the cross-reactive antigen precipitated with the H. influenzae type b capsular polysaccharide and had "protective" activity against H. influenzae type b in biologic assays. The cross-reactive antigen was identified in E. coli with various O and H serotypes and did not appear to be associated with pathogenicity.