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Development of Tissue Viral Resistance in Chickens Following Administration of Interferon Inducers¹

From the Irvington House Institute and Department of Medicine, New York University School of Medicine, New York, New York 10016

Abstract

Adult chickens were stimulated by various routes with interferon-inducers: poly rI/rC and statolon. After 7 or 24 hr they were sacrificed, their sera and tracheae were titered for interferon, and their tracheae and kidneys were examined for resistance to several different viruses. By this means the interferon-specificity of resistance could be judged, avoiding any non-interferon-mediated effects of the inducers. It was found that although poly rI/rC is a relatively poor interferon-inducer in chickens when given intramuscularly or intravenously it can induce interferon and viral resistance in the trachea when given locally. Statolon is ineffective when given intratracheally, but when given intravenously, induces considerable circulating interferon; this interferon seems to protect the kidney and to cross over into the trachea and protect that organ as well. The presence of high titers of interferon in the serum or trachea was associated with protection of the kidney or trachea respectively. However, the presence of small amounts of interferon or the absence of detectable interferon is not indicative of protection or a lack of protection. Interferon-like protection can be confined to specific organs depending upon the interferon-inducer used and its route of administration. These studies underscore the difficulty of equating the presence or absence of detectable interferon with tissue resistance and suggest that the technique of testing viral resistance of extirpated organs provides a valuable index of the efficacy of interferon inducers administered in vivo.

Footnotes

¹ This work was supported by United States Public Health Service Grant AI-09977-01-A1.

² This work was done during the tenure of an Established Investigatorship of the American Heart Association (AHA-71-142).