The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1972, 108: 1473-1481.
Copyright © 1972 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Terres, G.
Right arrow Articles by Stoner, R. D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Terres, G.
Right arrow Articles by Stoner, R. D.

Appearance of an Early "Primed State" in Mice following the Concomitant Injections of Antigen and Specific Antiserum1

Geronimo Terres2, Sherie L. Morrison, Gail S. Habicht2 and Richard D. Stoner3

From the Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, and the Division of Microbiology, Medical Research Center, Brookhaven National Laboratory, Upton, New York 11973

Abstract

Injection of mice with immune complexes formed with bovine serum albumin (BSA) and rabbit anti-BSA in antigen excess produced an enhanced anti-BSA response. An enhanced antibody response was also obtained when immune complexes prepared at equivalence were injected intravenously and a second antigen injection was made within 4 days. The results suggest that immune complexes elicit within a few days a "primed state" which is identical to the primed state observed weeks after a single antigen injection; that is, the kinetics of the appearance of antibody and the effect of whole-body irradiation upon the antibody response following the second antigen injection were similar to those observed in mice primed with antigen alone. The role of antibody and antigen-antibody complexes in eliciting a primed state is discussed.

Footnotes

1 This research was supported by United States Public Health Service Grant AI-09643-0 ALY and by the United States Atomic Energy Commission.

2 Department of Physiology, School of Medicine, Tufts University, Boston, Massachusetts. Address reprint requests to Dr. Terres.

3 Division of Microbiology, Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, New York.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1972 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1972 by The American Association of Immunologists, Inc. All rights reserved.