HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hirsch, M. S. Articles by Monaco, A. P. Search for Related Content PubMed Articles by Hirsch, M. S. Articles by Monaco, A. P.

Effects of Pyran Copolymer on Oncogenic Virus Infections in Immunosuppressed Hosts¹

From the Harvard Medical School, Department of Medicine and Surgery, Massachusetts General Hospital, and Sears Surgical Laboratories, Boston City Hospital, Boston, Massachusetts 02114

Abstract

The effects of pyran copolymer on polyoma virus oncogenesis and Rauscher virus leukemogenesis were evaluated in immunosuppressed mice. Mice immunosuppressed by adult thymectomy and antilymphocyte serum were protected by pyran copolymer against tumor development following subsequent polyoma virus inoculation. Similarly immunosuppressed mice were also protected against early erythroblastosis and late lymphomas induced by Rauscher virus. The mechanisms of protection appeared to be secondary to macrophage activation and enhanced phagocytosis induced by pyran copolymer.

Footnotes

¹ This investigation was supported by Public Health Service Grants CA-12464-01, CA-38802-02 and 8890-2.

This article has been cited by other articles:

				L. Seymour Review : Synthetic Polymers with Intrinsic Anticancer Activity Journal of Bioactive and Compatible Polymers, January 1, 1991; 6(2): 178 - 216. [PDF]

				M. S. Hirsch, D. A. Ellis, P. H. Black, A. P. Monaco, and M. L. Wood Leukemia Virus Activation during Homograft Rejection Science, May 4, 1973; 180(4085): 500 - 502. [Abstract] [PDF]