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The Journal of Immunology, 1972, 108: 1305-1311.
Copyright © 1972 by The American Association of Immunologists, Inc.
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The Effects of an Immunoenhancing Bacterial Product on the Adenyl Cyclase Activity of Mouse Spleen Cells

Richard Winchurch and Paul Actor

From the Department of Microbiology, Smith Kline & French Laboratories, Philadelphia, Pennsylvania 19101

Abstract

A somatic antigen fractionated from lysates of Vibrio cholerae was assessed for its ability to enhance responses to sheep and horse red blood cells (sRBC and hRBC). This material proved to possess adjuvant properties when injected with either of these antigens. In addition, this adjuvant substance was found to stimulate both tritiated thymidine uptake and adenyl cyclase activity in normal mouse spleen cell cultures.




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R. G. Kemp and R. J. Duquesnoy
Thymus Adenylate Cyclase Activity during Murine Leukemogenesis
Science, January 18, 1974; 183(4121): 218 - 219.
[Abstract] [PDF]


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