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Production of Chemotactic Activity by Guinea Pig Immunoglobulins Following Activation of the C3 Complement Shunt Pathway¹

From the Department of Medical Immunology, The Public Health Research Institute of the City of New York, Inc., New York, New York 10016, and the Laboratory of Microbiology, National Institute of Dental Research and the Laboratory of Clinical Investigation, National Institute of Allergy of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Guinea pig 1 and 2 immunoglobulins consume late C components (C3 to C9) when incubated with C4 deficient guinea pig serum. The 2 antibodies produce greater hemolytic activity losses in normal than in C4 deficient guinea pig serum. In contrast, consumption of late component activity by the 1 antibodies is similar in serum containing or lacking C4. Both types of immunoglobulins produce a serumderived factor chemotactic for rabbit polymorphonuclear leukocytes in either normal or C4 deficient serum. This factor has been identified as a cleavage product of C5.

Footnotes

¹ The term "C3 complement shunt" is used to designate an alternate mechanism for activating the complement system at the C3 step.

² Research Scientist, Bureau of Laboratories, New York City Department of Health.

³ The Department of Medical Immunology, The Public Health Research Institute of the City of New York, Inc., New York, N. Y. 10016. Supported in part by Grants from the National Science Foundation (GB1120), The American Cancer Society, Inc. (T-257) and the National Institute of Allergy and Infectious Diseases of the United States Public Health Service (AI-08710).

⁴ The Laboratory of Microbiology, National Institute of Dental Research, National Institutes of Health, Bethesda, Md. 20014. Present address: Department of Medicine, Duke University Medical Center, Durham, North Carolina 27706.

⁵ The Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20014.