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Genetic Control by the H-2 Gene Complex of the Alloantibody Response to an H-2 Antigen¹

From the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401

Abstract

The genetic control of the immune response against an H-2 antigenic specificity was investigated. With the aid of five congenic mouse strains, B10.A, C57BL/10, B10.A(2R), B10.A(3R) and B10.A(5R), it was demonstrated that a genetic factor, possibly Ir-1, associated with the H-2(K) subdivision of the H-2^b chromosome, exerts a regulatory effect on a recipient's capacity to respond to H-2.2, an antigenic specificity determined by the H-2(D) subdivision of the H-2 gene complex.

Footnotes

¹ This research was supported by a grant from the National Institutes of Health (AI-06525).

² Present address: 12 South Mountain Ave., Montclair, New Jersey, 07042.