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Genetic Control of Immune Response in Mice to a Glutamic Acid, Lysine, Phenylalanine Copolymer^1,2,3,

III. Use of Recombinant Inbred Strains of Mice to Establish Association of Immune Response Genes with H-2 Genotype

From the Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, and The Jackson Laboratory, Bar Harbor, Maine

Abstract

The ability of inbred mice to make a specific immune response to an optimal dose (10 µg) of the random copolymer GLØ is under the control of a distinct autosomal dominant gene. This gene is associated with the major histocompatibility locus of the species. Mice with the H-2 alleles d and q are responders, whereas those with alleles a, b, k, p and s are non-responders. This association with the H-2 locus was determined by use of recombinant-inbred strains and confirmed by the use of inbred and congenic strains. The application of RI strains to help identify Ir gene associations to H-2 is discussed.

Footnotes

¹ Supported by United States Public Health Research Grants AI 07825 from the National Institute of Allergy and Infectious Diseases and GM 15574 from the National Institute of General Medical Sciences and Research Grant T-452A from the American Cancer Society.

The Jackson Laboratory is fully accredited by the American Association of Laboratory Animal Care.

² Paper No. 52 in series on Antigenicity of Polypeptides (Poly Amino Acids).

³ Presented at First International Congress for Immunology, Washington, D. C., 1971.

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