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A Genetic Polymorphism of Peromyscus 7S₁ Globulins: Detection by Differences in Electrophoretic Mobility

From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana

Abstract

A genetic polymorphism for electrophoretic variants of the 7S₁ globulin in the deer mouse, Peromyscus maniculatus artemisiae, was demonstrated. The electrophoretic mobility of the 7S₁ globulin (or its Fc piece) in an individual serum represented one of three phenotypes—a relatively homogeneous fast or slow migration or a heterogeneous fast-slow mobility. All three phenotypes were detected in male and female mice from laboratory-reared and wild populations. Results of breeding experiments indicated that the electrophoretic variants were the result of two codominant alleles of the 7S₁ H chain gene. The unusual expression of 7S₁ allotype by electrophoretic variants in both Peromyscus and Mus musculus suggests that this mutational event occurred in a common ancestor.